Outcome of breast cancer in Iran: a study of Tehran Cancer Registry data.

BACKGROUND: Breast Cancer is the second most common cancer among Iranian women. This study was conducted to define the outcome of breast cancer which had been registered by Tehran Cancer Registry. METHODS: All Tehranian breast cancer which registered from 1998 to 2001 was selected; the repeated cases were excluded according to their common name, family name, and Father's name. A simple data collection form was used to complete the demographic and diagnostic time and survival situation of the cases by five educated technicians with using phone interviews with patients or their families. All data were entered in Access file and then exported to SPSS-11.5, for descriptive and analytic analysis, p value was significant under 0.05. Since there were some cases had not phone number or the phone numbers were not accessible; 360 cases were selected with Simple Random Sampling and their hospital files were reviewed to complete the demographic and location situations data. Kaplan- Meier regression model was used for computing the survival. RESULTS: Of the 7098 records, 4416 records were interviewed by phone. This phone interviews were succeeded among 2358 cases; Tehranian and other cities were defined in 986 and 1372 records respectively. The Tehranian cases were estimated 36.9% (CI95%: 31.9%-41.8%). The mean age of patients was 51.3+/-12.5, 31.4% of them was under 40 years old, the incidence rate of breast cancer in 100,000 women was estimated 17.09 CI95% (15.67-18.50). Infiltrating duct carcinoma was the most morphology (68.4%). Right, left, and both breast involvement were seen in 48.6% CI95% (43.4%-53.8%), 46.1% CI95 %( 41.0%-51.2%), 0.3% CI95%(0.1%-0.5%) respectively. The tumor size over 2 centimeters was seen in 63.6% of cases at diagnostic time. Lymphadenopathy and metastasis were seen in 48.3% CI95% (43.1%-53.5%), and 19.7% CI95% (15.6%-23.8%) of cases. The median survival was 5.0 years CI95% (4.9 years-5.1 years). CONCLUSION: This retrospective survival study was shown the seven years follow up from 1998 to 2005, women which were diagnosed in 1998, 1999, 2000, and 2001; 55.9%, 61.4%, 60.3%, 66% were alive respectively. Interventional projects for increasing the survival rate, early detection, and effective treatment of breast cancer were recommended.

Epidemiology of Kaposi's sarcoma in Iran: 1984-2006.

Kaposi's sarcoma (KS) is the rarest cancer among Iranian. This study was conducted to define the epidemiology of KS in Iran. The data of National Cancer Registry (NCR) reports from 2003-2006, Tehran Population Based Cancer Registry (TCR) from 1998 to 2001, and a literature review of the published articles until Aug. 2007 was conducted, the search strategy included all papers containing "Kaposi"were combined with the word "Iran" in their titles or abstracts. In males, the annual age-standardized incidence rate was from 0.10 to 0.17 per 100,000 and in females was from 0.06-0.08 per 100.000. Peak incidence was at ages 50-79. It is more common in male than female. The Male/Female ratio has different reports from 3.2/1 to 1.8/1. Although, there were no published reports about HHV-8 or HIV/AIDS associated with KS in Iran, the elderly might be a common associated factor for KS. The prognosis of KS after renal transplantation is good; simple reduction or cessation of immunosuppression may result in partial or complete remission of the disease.

Burden of breast cancer in Iran: a study of the Tehran population based cancer registry.

BACKGROUND: Breast cancer is the second most common cancer among Iranian women. This study was designed to estimate the burden of breast cancer in Tehran, the capital of Iran. METHODS: In this retrospective study, the existing data of Tehran Population Based Cancer Registry (TCR) from 1998 to 2001 were used; all Tehranian women with breast cancer were followed for computing the survival and remission rates. The World Health Organization's Practical Guide of National Burden of Disease Studies was employed for performing the study. The data for breast cancer were analyzed with DISMOD II software and Disability Adjusted Life Years (DALY) were computed using Excel based software. RESULTS: The mean age of the patients was 51.3+/-12.5, 31.4% being under 40 years old. The incidence rate of breast cancer was estimated to be 17.09 (95 %CI: 15.67-18.50) per 100,000 women. The five year survival rate was 75 %. The DALY for breast cancer was 4,252 years (95 %CI: 3896-4604). CONCLUSION: Breast cancer is a high burden in the community. More than 36% of the tumors occur in women under 40 years old. Comprehensive national cancer control programs including promotion of awareness, early detection, treatment and palliative cares are vitally important for decreasing the burden of breast cancer in Iran. This strategy should be strongly recommended to policy makers and special programs should be considered for women under 40 years old.